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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)

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Studies have shown that individuals with ASD often exhibit imbalances in their gut microbiota composition compared to neurotypical individuals

Peer review Peer review information Nature Reviews Molecular Cell Biology thanks Charles Brenner, Evandro Fang and Lindsay Wu for their contribution to the peer review of this work